DelsaMax PRO and CORE Analysers

DelsaMax CORE – Beckman Coulter

DelsaMax CORE

Depending on your specific particle characterisation needs, the main choice you will need to make within the new DelsaMax range of dynamic light scattering instruments from Beckman Coulter might well be between the PRO and CORE versions. A little summary here might help.

If extremely quick – as well as reliable – measurement of both particle size and zeta potential is your goal, the DelsaMax PRO may be your first choice. When it comes to measuring electrophoretic mobility, or zeta potential as it is alternatively known, the PRO will not only deal rapidly with large particles – such as virus-like particles and liposomes – but will reliably tackle the measurement of a variety of protein samples which have proved to be a great challenge in the past. These include, for example, antibody formulations, bovine serum albumins and lysozymes.

The PRO features a quasi elastic light scattering facility which, at the same time, allows the hydrodynamic radii of macromolecules to be determined. Back-scattered light is used in measuring the sample’s translational diffusion coefficient.

Zeta potential and QELS determinations involve use of a flow-through cell, with plumbing configured for flow or batch. Importantly, there is no need to halt the flow to measure electrophoretic mobility. You can introduce a sample manually or by means of autosampling, syringe pump or auto-titration equipment. Other features of the PRO include its temperature control function, which can be used in carrying out automated temperature studies

Those choosing the DelsaMax CORE may be particularly interested in its remarkable sensitivity and accuracy. For measurement of particle size, a sample volume of 1 µl is enough.

The CORE combines dynamic light scattering with SLS (static light scattering). While the dynamic light scattering detector, operating at an angle of 90 degrees, determines hydrodynamic radius, the SLS detector, operating at the same angle, independently measures the molecular weight of small molecules in the sample. Nanoparticles, proteins, vesicles, viruses and colloids are among the many materials which can be studied using this instrument.